BDBM50535382 CHEMBL4588863

SMILES CC(C)c1onc(c1COc1ccc(COc2cccc(c2)C(O)=O)cc1)-c1c(Cl)cccc1Cl

InChI Key InChIKey=GEWMZQKEIXGPNU-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50535382   

TargetBile acid receptor(Human)
University of Naples "Federico II"

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50535382BDBM50535382(CHEMBL4588863)
Affinity DataEC50:  460nMAssay Description:Inhibition of GSK3beta-mediated CRMP-2 phosphorylation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetBile acid receptor(Human)
University of Naples "Federico II"

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50535382BDBM50535382(CHEMBL4588863)
Affinity DataEC50:  460nMAssay Description:Inhibition of GSK3beta-mediated CRMP-2 phosphorylation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetBile acid receptor(Human)
University of Naples "Federico II"

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50535382BDBM50535382(CHEMBL4588863)
Affinity DataEC50:  460nMAssay Description:Transactivation of human FXR (unknown origin) expressed in HepG2 cells co-expressing pSG5RXR/pGL4.70 after 24 hrs post transfection by luciferase rep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetBile acid receptor(Human)
University of Naples "Federico II"

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50535382BDBM50535382(CHEMBL4588863)
Affinity DataEC50:  1.40E+3nMAssay Description:Agonist activity at FXR in human HepG2 cells by luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetLeukemia inhibitory factor receptor(Homo sapiens)
University of Naples "Federico II"

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50535382BDBM50535382(CHEMBL4588863)
Affinity DataIC50: 6.11E+3nMAssay Description:Inhibition of GSK3beta-mediated CRMP-2 phosphorylation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetLeukemia inhibitory factor receptor(Homo sapiens)
University of Naples "Federico II"

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50535382BDBM50535382(CHEMBL4588863)
Affinity DataIC50: 6.11E+3nMAssay Description:Inhibition of BACE1 assessed as inhibition of amyloid beta-40 production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed