BDBM50535489 CHEMBL4471729

SMILES Nc1ncc(Br)c2ccc(nc12)-c1ccnc(F)c1

InChI Key InChIKey=KARJFNUGCLEZKM-UHFFFAOYSA-N

Data  8 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50535489   

TargetTRAF2 and NCK-interacting protein kinase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50535489(CHEMBL4471729)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of human full length TNIK(1-1360)-G5-Avi-6His-Flag expressed in baculovirus-infected sf21 cells using His6-SMAD1 as substrate preincubated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM50535489(CHEMBL4471729)
Affinity DataIC50:  32nMAssay Description:Inhibition of human 6His-TEV-SHM-MAP4K4(2 to 328)-GNS expressed in baculovirus-infected sf21 cells using LRRKtide as substrate preincubated for 30 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetTRAF2 and NCK-interacting protein kinase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50535489(CHEMBL4471729)
Affinity DataIC50:  13nMAssay Description:Inhibition of human 6His-TEV-TNIK(1 to 325) expressed in baculovirus-infected sf21 cells using LRRKtide as substrate preincubated for 30 mins followe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetTRAF2 and NCK-interacting protein kinase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50535489(CHEMBL4471729)
Affinity DataIC50:  1.26E+3nMAssay Description:Inhibition of human full length TNIK in HEK293 cells co-transfected with full length SMAD1 incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetMisshapen-like kinase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50535489(CHEMBL4471729)
Affinity DataIC50:  13nMAssay Description:Inhibition of human full length MINK1(1-1332)-G5-Avi-6His-Flag expressed in baculovirus-infected sf21 cells using His6-SMAD1 as substrate preincubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetMisshapen-like kinase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50535489(CHEMBL4471729)
Affinity DataIC50:  50nMAssay Description:Inhibition of human 6His-TEV-Avi-MINK1(1 to 328)-GNS expressed in baculovirus-infected sf21 cells using LRRKtide as substrate preincubated for 30 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM50535489(CHEMBL4471729)
Affinity DataIC50:  20nMAssay Description:Inhibition of human full length MAP4K4(1-1239)-G5-Avi-6His-Flag expressed in baculovirus-infected sf21 cells using His6-SMAD1 as substrate preincubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetTRAF2 and NCK-interacting protein kinase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50535489(CHEMBL4471729)
Affinity DataIC50:  1.25E+3nMAssay Description:Inhibition of human full length TNIK in HEK293 cells co-transfected with full length SMAD1 incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)