BDBM50536426 CHEMBL4522536

SMILES CC(C)C[C@H](NC(=O)CN1CCOCC1)C(=O)N[C@@H](C[C@H]1CC[C@@H](CC1)C1CCCCC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)[C@@]1(C)CO1

InChI Key InChIKey=MUNPGSOQSQLUNU-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50536426   

TargetProteasome subunit beta type-5(Human)
Leiden Institute of Chemistry

Curated by ChEMBL
LigandPNGBDBM50536426(CHEMBL4522536)
Affinity DataIC50: 28nMAssay Description:Inhibition of catalytic activity of constitutive proteasome 20s subunit beta5 in human Raji cells incubated for 1 hr by BODIPY(TMR)-NC-005-VS probe b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-5(Human)
Leiden Institute of Chemistry

Curated by ChEMBL
LigandPNGBDBM50536426(CHEMBL4522536)
Affinity DataIC50: 28nMAssay Description:Inhibition of 20s constitutive proteasome beta-5c (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetProteasome subunit beta type-5(Human)
Leiden Institute of Chemistry

Curated by ChEMBL
LigandPNGBDBM50536426(CHEMBL4522536)
Affinity DataIC50: 274nMAssay Description:Inhibition of catalytic activity of constitutive proteasome 20s subunit beta5 in human RPMI8226 cells incubated for 1 hr by BODIPY(TMR)-NC-005-VS pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-8(Human)
Weill Cornell Medicine

Curated by ChEMBL
LigandPNGBDBM50536426(CHEMBL4522536)
Affinity DataIC50: 2.28E+4nMAssay Description:Inhibition of 20s immunoproteasome beta-5i subunit (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetProteasome subunit beta type-5(Human)
Leiden Institute of Chemistry

Curated by ChEMBL
LigandPNGBDBM50536426(CHEMBL4522536)
Affinity DataIC50: 2.28E+4nMAssay Description:Inhibition of catalytic activity of immunoproteasome 20s subunit beta5 in human Raji cells incubated for 1 hr by BODIPY(TMR)-NC-005-VS probe based co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-2(Human)
Leiden Institute of Chemistry

Curated by ChEMBL
LigandPNGBDBM50536426(CHEMBL4522536)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of catalytic activity of immunoproteasome 20s subunit beta2 in human RPMI8226 cells incubated for 1 hr by BODIPY(FL)-LU-112 probe based co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-2(Human)
Leiden Institute of Chemistry

Curated by ChEMBL
LigandPNGBDBM50536426(CHEMBL4522536)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of catalytic activity of immunoproteasome 20s subunit beta2 in human Raji cells incubated for 1 hr by BODIPY(FL)-LU-112 probe based compet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-1(Human)
Leiden Institute of Chemistry

Curated by ChEMBL
LigandPNGBDBM50536426(CHEMBL4522536)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of catalytic activity of constitutive proteasome 20s subunit beta1 in human RPMI8226 cells incubated for 1 hr by Cy5-NC-001 probe based co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-5(Human)
Leiden Institute of Chemistry

Curated by ChEMBL
LigandPNGBDBM50536426(CHEMBL4522536)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of catalytic activity of immunoproteasome 20s subunit beta5 in human RPMI8226 cells incubated for 1 hr by BODIPY(TMR)-NC-005-VS probe base...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-1(Human)
Leiden Institute of Chemistry

Curated by ChEMBL
LigandPNGBDBM50536426(CHEMBL4522536)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of catalytic activity of immunoproteasome 20s subunit beta1 in human Raji cells incubated for 1 hr by Cy5-NC-001 probe based competitive a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-2(Human)
Leiden Institute of Chemistry

Curated by ChEMBL
LigandPNGBDBM50536426(CHEMBL4522536)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of catalytic activity of constitutive proteasome 20s subunit beta2 in human RPMI8226 cells incubated for 1 hr by BODIPY(FL)-LU-112 probe b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-1(Human)
Leiden Institute of Chemistry

Curated by ChEMBL
LigandPNGBDBM50536426(CHEMBL4522536)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of catalytic activity of immunoproteasome 20s subunit beta1 in human RPMI8226 cells incubated for 1 hr by Cy5-NC-001 probe based competiti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-1(Human)
Leiden Institute of Chemistry

Curated by ChEMBL
LigandPNGBDBM50536426(CHEMBL4522536)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of catalytic activity of constitutive proteasome 20s subunit beta1 in human Raji cells incubated for 1 hr by Cy5-NC-001 probe based compet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetProteasome subunit beta type-2(Human)
Leiden Institute of Chemistry

Curated by ChEMBL
LigandPNGBDBM50536426(CHEMBL4522536)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of catalytic activity of constitutive proteasome 20s subunit beta2 in human Raji cells incubated for 1 hr by BODIPY(FL)-LU-112 probe based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed