BDBM50536646 CHEMBL4557930

SMILES COc1ccc(cn1)-c1c(CO)n(Cc2ccccc2Cl)c2ccc(OC(F)(F)F)cc12

InChI Key InChIKey=YYPCMHMJIQOTMJ-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50536646   

TargetCytochrome P450 3A4(Homo sapiens (Human))
Northwest Agriculture & Forestry University

Curated by ChEMBL
LigandPNGBDBM50536646(CHEMBL4557930)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes incubated for 15 mins using midazolam substrate in presence of NADPH by LC-MS/MS methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Northwest Agriculture & Forestry University

Curated by ChEMBL
LigandPNGBDBM50536646(CHEMBL4557930)
Affinity DataIC50:  9.40E+3nMAssay Description:Antagonist activity at PAR4 TL domain in human platelets assessed as gamma-thrombin-induced PAC1 binding response preincubated for 20 mins followed b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Northwest Agriculture & Forestry University

Curated by ChEMBL
LigandPNGBDBM50536646(CHEMBL4557930)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of CYP1A2 in human liver microsomes incubated for 15 mins using phenacetin substrate in presence of NADPH by LC-MS/MS methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Northwest Agriculture & Forestry University

Curated by ChEMBL
LigandPNGBDBM50536646(CHEMBL4557930)
Affinity DataIC50:  490nMAssay Description:Antagonist activity against PAR4 activating peptide domain in human platelets assessed as inhibition of alpha2bbeta3 activation level by PAC1 binding...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Northwest Agriculture & Forestry University

Curated by ChEMBL
LigandPNGBDBM50536646(CHEMBL4557930)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of PAR1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Northwest Agriculture & Forestry University

Curated by ChEMBL
LigandPNGBDBM50536646(CHEMBL4557930)
Affinity DataIC50:  435nMAssay Description:Antagonist activity against PAR4 activating peptide domain in in human platelets assessed as inhibition of P-selectin activationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Northwest Agriculture & Forestry University

Curated by ChEMBL
LigandPNGBDBM50536646(CHEMBL4557930)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at PAR4 TL domain in human platelets assessed as gamma-thrombin-induced P-selectin activation preincubated for 20 mins followed b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Northwest Agriculture & Forestry University

Curated by ChEMBL
LigandPNGBDBM50536646(CHEMBL4557930)
Affinity DataIC50:  6.80E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes incubated for 15 mins using diclofenac substrate in presence of NADPH by LC-MS/MS methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Northwest Agriculture & Forestry University

Curated by ChEMBL
LigandPNGBDBM50536646(CHEMBL4557930)
Affinity DataIC50:  120nMAssay Description:Inhibition of CYP2D6 in human liver microsomes incubated for 15 mins using dextromethorphan substrate in presence of NADPH by LC-MS/MS methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 4(Homo sapiens (Human))
Northwest Agriculture & Forestry University

Curated by ChEMBL
LigandPNGBDBM50536646(CHEMBL4557930)
Affinity DataIC50:  450nMAssay Description:Antagonist activity against PAR4 activating peptide domain in human platelets assessed as inhibition of alpha2bbeta3 activation level by PAC1 binding...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed