BDBM50537599 CHEMBL4648060::US11149020, Compound 2 (MW-108)

SMILES CN(C)c1cc(-c2ccncc2)c(nn1)-c1ccc2ccccc2c1

InChI Key InChIKey=ODFGOBPLQKLCRM-UHFFFAOYSA-N

Data  2 KI  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50537599   

TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50537599(CHEMBL4648060 | US11149020, Compound 2 (MW-108))
Affinity DataKi:  110nMAssay Description:Inhibitory activity against HIV-1 Mutant Reverse transcriptase G190AMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50537599(CHEMBL4648060 | US11149020, Compound 2 (MW-108))
Affinity DataKi:  114nMAssay Description:The concentration dependent ability of compounds to inhibit human p38α MAPK, p38β MAPK and CK-1δ were done essentially as described in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCasein kinase I isoform delta(Homo sapiens (Human))
The Trustees of Columbia University In The City of New York

US Patent
LigandPNGBDBM50537599(CHEMBL4648060 | US11149020, Compound 2 (MW-108))
Affinity DataIC50:  6.12E+3nMAssay Description:The concentration dependent ability of compounds to inhibit human p38α MAPK, p38β MAPK and CK-1δ were done essentially as described in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetCasein kinase I isoform delta(Homo sapiens (Human))
The Trustees of Columbia University In The City of New York

US Patent
LigandPNGBDBM50537599(CHEMBL4648060 | US11149020, Compound 2 (MW-108))
Affinity DataIC50:  6.65E+3nMAssay Description:Inhibitory activity against HIV-1 Mutant Reverse transcriptase P236LMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50537599(CHEMBL4648060 | US11149020, Compound 2 (MW-108))
Affinity DataIC50:  210nMAssay Description:Inhibitory activity against HIV-1 Y181C reverse transcriptase.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50537599(CHEMBL4648060 | US11149020, Compound 2 (MW-108))
Affinity DataIC50:  3.03E+3nMAssay Description:Inhibitory activity against HIV-1 Mutant Reverse transcriptase G190AMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50537599(CHEMBL4648060 | US11149020, Compound 2 (MW-108))
Affinity DataIC50:  236nMAssay Description:The concentration dependent ability of compounds to inhibit human p38α MAPK, p38β MAPK and CK-1δ were done essentially as described in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB