BDBM50540495 CHEMBL4127849::acs.jmedchem.1c00409_ST.281

SMILES Clc1ccc(SSc2nccs2)cc1

InChI Key InChIKey=VWPWGCSEEUQWCP-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50540495   

TargetFructose-1,6-bisphosphatase 1(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50540495(CHEMBL4127849 | acs.jmedchem.1c00409_ST.281)
Affinity DataIC50: 540nMAssay Description:Inhibition of wild-type full-length human liver FBPase expressed in Escherichia coli BL21 (DE3) using FBP as substrate incubated for 5 mins by malach...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetFructose-1,6-bisphosphatase 1(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50540495(CHEMBL4127849 | acs.jmedchem.1c00409_ST.281)
Affinity DataIC50: 640nMAssay Description:Inhibition of human liver FBPase C92S mutant expressed in Escherichia coli BL21 (DE3) using FBP as substrate incubated for 5 mins by malachite green ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetFructose-1,6-bisphosphatase 1(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50540495(CHEMBL4127849 | acs.jmedchem.1c00409_ST.281)
Affinity DataIC50: 670nMAssay Description:Inhibition of human liver FBPase C179S mutant expressed in Escherichia coli BL21 (DE3) using FBP as substrate incubated for 5 mins by malachite green...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetFructose-1,6-bisphosphatase 1(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50540495(CHEMBL4127849 | acs.jmedchem.1c00409_ST.281)
Affinity DataIC50: 850nMAssay Description:Inhibition of human liver FBPase C116S mutant expressed in Escherichia coli BL21 (DE3) using FBP as substrate incubated for 5 mins by malachite green...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetFructose-1,6-bisphosphatase 1(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50540495(CHEMBL4127849 | acs.jmedchem.1c00409_ST.281)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human liver FBPase C183S mutant expressed in Escherichia coli BL21 (DE3) using FBP as substrate incubated for 5 mins by malachite green...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetFructose-1,6-bisphosphatase 1(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50540495(CHEMBL4127849 | acs.jmedchem.1c00409_ST.281)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human liver FBPase C281S mutant expressed in Escherichia coli BL21 (DE3) using FBP as substrate incubated for 5 mins by malachite green...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
Michigan State University

LigandPNGBDBM50540495(CHEMBL4127849 | acs.jmedchem.1c00409_ST.281)
Affinity DataIC50: 1.87E+3nMAssay Description:This is a review article. Please point to the original journal.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2022
Entry Details Article
PubMed
TargetFructose-1,6-bisphosphatase 1(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50540495(CHEMBL4127849 | acs.jmedchem.1c00409_ST.281)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of human liver FBPase C38S mutant expressed in Escherichia coli BL21 (DE3) using FBP as substrate incubated for 5 mins by malachite green ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetFructose-1,6-bisphosphatase 1(Human)
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50540495(CHEMBL4127849 | acs.jmedchem.1c00409_ST.281)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of human liver FBPase C128S mutant expressed in Escherichia coli BL21 (DE3) using FBP as substrate incubated for 5 mins by malachite green...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed