BDBM505405 8-chloro-4-(((R)-3-cyano-1-phenyl- propyl)amino)-6-(((S)-(1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(isoindolin-4- yl)methyl)amino)quinoline-3- carbonitrile::BDBM505459::US11066414, Compound 68

SMILES N#CCC[C@@H](Nc1c(C#N)cnc2c(Cl)cc(N[C@H](C3=CN(C4CC4)NN3)c3cccc4c3CNC4)cc12)c1ccccc1

InChI Key InChIKey=JEPNWFYQHHQDJU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 505405   

TargetEpidermal growth factor receptor(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 505405BDBM505405(8-chloro-4-(((R)-3-cyano-1-phenyl- propyl)amino)-6...)
Affinity DataIC50: 1nMAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2021
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 505405BDBM505405(8-chloro-4-(((R)-3-cyano-1-phenyl- propyl)amino)-6...)
Affinity DataIC50: 6nMAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2021
Entry Details
US Patent