BDBM50540743 CHEMBL4641148::US11472795, Example 18

SMILES OCc1ccncc1-c1ccc2[nH]nc(C(=O)NCC3CCOCC3)c2c1

InChI Key InChIKey=JIRLCHVAMIDNRT-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50540743   

TargetGlycogen synthase kinase-3 beta(Human)
Angelini Pharma

Curated by ChEMBL
LigandPNGBDBM50540743(CHEMBL4641148 | US11472795, Example 18)
Affinity DataIC50: 33nMAssay Description:Inhibition of recombinant full length human N-terminal GST-tagged GSK3beta (1 to 420 end residues) expressed in baculovirus expression system using u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Angelini Pharma

Curated by ChEMBL
LigandPNGBDBM50540743(CHEMBL4641148 | US11472795, Example 18)
Affinity DataIC50: 33nMAssay Description:The activity on human GSK-3β of the compounds of the invention listed in the following Table 1 and of the comparison compound C was assessed at ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Angelini Acraf

US Patent
LigandPNGBDBM50540743(CHEMBL4641148 | US11472795, Example 18)
Affinity DataIC50: 4.10E+4nMAssay Description:Confirmation of interaction with the potassium channels of the compounds of the invention listed in the following Table 1 and of the comparison compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2022
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Angelini Acraf

US Patent
LigandPNGBDBM50540743(CHEMBL4641148 | US11472795, Example 18)
Affinity DataIC50: 4.13E+4nMAssay Description:Inhibition of human ERG expressed in CHOK1 cells assessed as reduction in tail current by measuring tail current amplitude measured after deploarizat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed