BDBM505409 8-chloro-4-(((R)-3-cyano-1-phenyl- propyl)amino)-6-(((1-cyclopropyl- 1H-1,2,3-triazol-4-yl)(6-fluoro-2- methylpyridin-3-yl)methyl- d)amino)quinoline-3-carbonitrile::BDBM505463::US11066414, Compound 72

SMILES Cc1nc(F)ccc1[C@](O)(Nc1cc(Cl)c2ncc(C#N)c(N[C@H](CCC#N)c3ccccc3)c2c1)C1=CN(NN1)C1CC1

InChI Key InChIKey=RWRNVEHWPKZJPJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 505409   

TargetEpidermal growth factor receptor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM505409(8-chloro-4-(((R)-3-cyano-1-phenyl- propyl)amino)-6...)
Affinity DataIC50: 1nMAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2021
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM505409(8-chloro-4-(((R)-3-cyano-1-phenyl- propyl)amino)-6...)
Affinity DataIC50: 7nMAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2021
Entry Details
US Patent