BDBM50541803 CHEMBL4642490

SMILES CS(=O)(=O)c1sc(c2CCC(F)(F)[C@@H](O)c12)-c1cc(Cl)nc(c1)C#N

InChI Key InChIKey=NNGUTMALIFNSPA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50541803   

TargetEndothelial PAS domain-containing protein 1(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM50541803(CHEMBL4642490)
Affinity DataIC50: 50nMAssay Description:Inhibition of human recombinant His6Gb1-tagged HIF2alpha PAS B domain (240 to 350 residues)/human recombinant His6/FLAG-tagged ARNT PAS B domain (356...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM50541803(CHEMBL4642490)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of HIF2-alpha in human 786-0 cells cells harboring HRE-Luc2P reporter construct incubated for 48 hrs by ONE-Glo EX reagent based luminesce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed