BDBM50542083 CHEMBL4633886

SMILES CC1CN(CCOc2cc(F)c([C@H]3N(CC(C)(C)F)[C@H](C)Cc4c3[nH]c3ccccc43)c(F)c2)C1

InChI Key InChIKey=SZSVDSDJAHXIIN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50542083   

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM50542083(CHEMBL4633886 | US20250114338, Example 140)
Affinity DataEC50:  0.130nMAssay Description:All of the exemplary Formula I compounds in Tables 1 and 2 were tested for binding to ERa (Estrogen Receptor alpha) and biological activity according...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2025
Entry Details

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM50542083(CHEMBL4633886 | US20250114338, Example 140)
Affinity DataIC50: 0.190nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by FITC/Hoechst staining based immunofluorescence imaging analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed