BDBM50542091 CHEMBL4640902

SMILES C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1CC(C)(C)F)c1c(F)cc(OC2CN(CCF)C2)cc1F

InChI Key InChIKey=WMVQBWDBJJRNKU-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50542091   

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM50542091(CHEMBL4640902 | US20250114338, Example 166)
Affinity DataEC50:  0.175nMAssay Description:All of the exemplary Formula I compounds in Tables 1 and 2 were tested for binding to ERa (Estrogen Receptor alpha) and biological activity according...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2025
Entry Details

TargetEstrogen receptor(Human)
Genentech

US Patent
LigandPNGBDBM50542091(CHEMBL4640902 | US20250114338, Example 166)
Affinity DataIC50: 0.180nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by FITC/Hoechst staining based immunofluorescence imaging analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed