BDBM50544204 CHEMBL4643371

SMILES CC(C)Nc1cc(Nc2ccc3nc(C)sc3c2)ncc1C(=O)NC[C@@H](F)C(C)(C)O

InChI Key InChIKey=QVXBJWIDBUXXFC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50544204   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Biocon Bristol Myers Squibb Research Center

Curated by ChEMBL
LigandPNGBDBM50544204(CHEMBL4643371)
Affinity DataIC50: 8nMAssay Description:Inhibition of IRAK4 (unknown origin) using FL-IPTSPITTTYFFFKKK peptide and ATP as substrate incubated for 60 mins by fluorescence based caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Biocon Bristol Myers Squibb Research Center

Curated by ChEMBL
LigandPNGBDBM50544204(CHEMBL4643371)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as inhibition of LTA-induced IL-6 production preincubated for 30 mins followed by LTA-stimulation and meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Biocon Bristol Myers Squibb Research Center

Curated by ChEMBL
LigandPNGBDBM50544204(CHEMBL4643371)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of IRAK4 in human whole blood assessed as inhibition of LTA-induced IL-6 production preincubated for 30 mins followed by LTA-stimulation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed