BDBM50544427 CHEMBL4632818::US11192850, Entry 4g
SMILES CN(C)c1cc(O)c(cc1C#Cc1cccc(NC(=O)C(O)=O)c1)C(O)=O
InChI Key InChIKey=GNKSSXOYTYJLKA-UHFFFAOYSA-N
Data 29 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 29 hits for monomerid = 50544427
TargetTYR_PHOSPHATASE_2 domain-containing protein(Mycobacterium tuberculosis)
Purdue University
Curated by ChEMBL
Purdue University
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Inhibition of Mycobacterium tuberculosis PTPB expressed in Escherichia coli BL21 (DE3) using p-nitrophenyl phosphate as substrate measured after 30 m...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Purdue Research Foundation
US Patent
Purdue Research Foundation
US Patent
Affinity DataIC50: 4.51E+4nMAssay Description:Compounds were tested against mPTPB using the p-nitrophenyl phosphate (pNPP) assay system in a Cary 100 UV-Vis spectrophotometer by monitoring the in...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Purdue Research Foundation
US Patent
Purdue Research Foundation
US Patent
Affinity DataIC50: 4.51E+4nMAssay Description:Inhibition of PTP1B (unknown origin) expressed in Escherichia coli BL21 using p-nitrophenyl phosphate as substrate measured after 30 mins by UV-vis s...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Purdue University
Curated by ChEMBL
Purdue University
Curated by ChEMBL
Affinity DataIC50: 3.85E+4nMAssay Description:Inhibition of SHP1 (unknown origin) expressed in Escherichia coli BL21 using p-nitrophenyl phosphate as substrate measured after 30 mins by UV-vis sp...More data for this Ligand-Target Pair
TargetLow molecular weight protein-tyrosine phosphatase A(Mycobacterium tuberculosis)
Purdue University
Curated by ChEMBL
Purdue University
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis PTPA using p-nitrophenyl phosphate as substrate measured after 30 mins by UV-vis spectrophotometric methodMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Purdue University
Curated by ChEMBL
Purdue University
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of TCPTP (unknown origin) expressed in Escherichia coli BL21 using p-nitrophenyl phosphate as substrate measured after 30 mins by UV-vis s...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 22(Homo sapiens (Human))
Purdue University
Curated by ChEMBL
Purdue University
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of LYP (unknown origin) expressed in Escherichia coli BL21 using p-nitrophenyl phosphate as substrate measured after 30 mins by UV-vis spe...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 7(Homo sapiens (Human))
Purdue University
Curated by ChEMBL
Purdue University
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of HePTP (unknown origin) expressed in Escherichia coli BL21 using p-nitrophenyl phosphate as substrate measured after 30 mins by UV-vis s...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 13(Homo sapiens (Human))
Purdue University
Curated by ChEMBL
Purdue University
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of FAP1 (unknown origin) expressed in Escherichia coli BL21 using p-nitrophenyl phosphate as substrate measured after 30 mins by UV-vis sp...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein phosphatase eta(Homo sapiens (Human))
Purdue University
Curated by ChEMBL
Purdue University
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of DEP1 (unknown origin) expressed in Escherichia coli BL21 using p-nitrophenyl phosphate as substrate measured after 30 mins by UV-vis sp...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of Laforin (unknown origin) expressed in Escherichia coli BL21 using p-nitrophenyl phosphate as substrate measured after 30 mins by UV-vis...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 9(Homo sapiens (Human))
Purdue University
Curated by ChEMBL
Purdue University
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of PTP-MEG2 (unknown origin) expressed in Escherichia coli BL21 using p-nitrophenyl phosphate as substrate measured after 30 mins by UV-vi...More data for this Ligand-Target Pair
TargetDual specificity protein phosphatase 6(Homo sapiens (Human))
Purdue University
Curated by ChEMBL
Purdue University
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of MKP3 (unknown origin) expressed in Escherichia coli BL21 using p-nitrophenyl phosphate as substrate measured after 30 mins by UV-vis sp...More data for this Ligand-Target Pair
TargetDual specificity protein phosphatase 10(Homo sapiens (Human))
Purdue University
Curated by ChEMBL
Purdue University
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of MKP5 (unknown origin) expressed in Escherichia coli BL21 using p-nitrophenyl phosphate as substrate measured after 30 mins by UV-vis sp...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 12(Homo sapiens (Human))
Purdue University
Curated by ChEMBL
Purdue University
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of PTP-PEST (unknown origin) expressed in Escherichia coli BL21 using p-nitrophenyl phosphate as substrate measured after 30 mins by UV-vi...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein phosphatase C(Homo sapiens (Human))
Purdue University
Curated by ChEMBL
Purdue University
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CD45 (unknown origin) expressed in Escherichia coli BL21 using p-nitrophenyl phosphate as substrate measured after 30 mins by UV-vis sp...More data for this Ligand-Target Pair
TargetDual specificity protein phosphatase CDC14A(Homo sapiens (Human))
Purdue University
Curated by ChEMBL
Purdue University
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CDC14A (unknown origin) expressed in Escherichia coli BL21 using p-nitrophenyl phosphate as substrate measured after 30 mins by UV-vis ...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 5(Homo sapiens (Human))
Purdue University
Curated by ChEMBL
Purdue University
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of STEP (unknown origin) expressed in Escherichia coli BL21 using p-nitrophenyl phosphate as substrate measured after 30 mins by UV-vis sp...More data for this Ligand-Target Pair
TargetDual specificity protein phosphatase 3(Homo sapiens (Human))
Purdue University
Curated by ChEMBL
Purdue University
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of VHR (unknown origin) expressed in Escherichia coli BL21 using p-nitrophenyl phosphate as substrate measured after 30 mins by UV-vis spe...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of PTPS (unknown origin) expressed in Escherichia coli BL21 using p-nitrophenyl phosphate as substrate measured after 30 mins by UV-vis sp...More data for this Ligand-Target Pair
TargetSerine/threonine-protein phosphatase 2A activator(Homo sapiens (Human))
Purdue University
Curated by ChEMBL
Purdue University
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of PTPA (unknown origin) expressed in Escherichia coli BL21 using p-nitrophenyl phosphate as substrate measured after 30 mins by UV-vis sp...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Purdue University
Curated by ChEMBL
Purdue University
Curated by ChEMBL
Affinity DataIC50: 1.15E+4nMAssay Description:Inhibition of PTPB (unknown origin) expressed in Escherichia coli BL21 using p-nitrophenyl phosphate as substrate measured after 30 mins by UV-vis sp...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein phosphatase mu(Homo sapiens (Human))
Purdue University
Curated by ChEMBL
Purdue University
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of PTPM (unknown origin) expressed in Escherichia coli BL21 using p-nitrophenyl phosphate as substrate measured after 30 mins by UV-vis sp...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein phosphatase gamma(Homo sapiens (Human))
Purdue University
Curated by ChEMBL
Purdue University
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of PTPG (unknown origin) expressed in Escherichia coli BL21 using p-nitrophenyl phosphate as substrate measured after 30 mins by UV-vis sp...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein phosphatase epsilon(Homo sapiens (Human))
Purdue University
Curated by ChEMBL
Purdue University
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of PTPE (unknown origin) expressed in Escherichia coli BL21 using p-nitrophenyl phosphate as substrate measured after 30 mins by UV-vis sp...More data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Compounds were tested against mPTPB using the p-nitrophenyl phosphate (pNPP) assay system in a Cary 100 UV-Vis spectrophotometer by monitoring the in...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Purdue Research Foundation
US Patent
Purdue Research Foundation
US Patent
Affinity DataIC50: 4.75E+4nMAssay Description:Compounds were tested against mPTPB using the p-nitrophenyl phosphate (pNPP) assay system in a Cary 100 UV-Vis spectrophotometer by monitoring the in...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Purdue University
Curated by ChEMBL
Purdue University
Curated by ChEMBL
Affinity DataIC50: 3.85E+4nMAssay Description:Compounds were tested against mPTPB using the p-nitrophenyl phosphate (pNPP) assay system in a Cary 100 UV-Vis spectrophotometer by monitoring the in...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Purdue Research Foundation
US Patent
Purdue Research Foundation
US Patent
Affinity DataIC50: 4.75E+4nMAssay Description:Inhibition of SHP2 (unknown origin) expressed in Escherichia coli BL21 using p-nitrophenyl phosphate as substrate measured after 30 mins by UV-vis sp...More data for this Ligand-Target Pair