BDBM50544501 CHEMBL4647444

SMILES COC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1Cc1ccccc1)c1ccccc1

InChI Key InChIKey=CXXMITPJMNSSPY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50544501   

LigandPNGBDBM50544501(CHEMBL4647444)
Affinity DataIC50: 12nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK-293/TRPM8 exon1 K3 cells assessed as inhibition of menthol-induced current response by whole-cell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM50544501(CHEMBL4647444)
Affinity DataIC50: 900nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50544501(CHEMBL4647444)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human Nav1.7 expressed in HEK293 cells assessed as inhibition of veratridine-induced increase in calcium flux by FLIPR dye bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed