BDBM50544782 CHEMBL4643899

SMILES N#C[C@]1(C2CC2)C(=O)N2C[C@H]1COC/C=C\COCc1cccc(n1)Nc1cc2ccn1

InChI Key InChIKey=HTEKLZHVQBWTOT-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50544782   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50544782BDBM50544782(CHEMBL4643899)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of TYK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50544782BDBM50544782(CHEMBL4643899)
Affinity DataIC50: 130nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50544782BDBM50544782(CHEMBL4643899)
Affinity DataIC50: 260nMAssay Description:Inhibition of TYK2 in human Jurkat cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50544782BDBM50544782(CHEMBL4643899)
Affinity DataIC50: 270nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50544782BDBM50544782(CHEMBL4643899)
Affinity DataIC50: 580nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed