BDBM50544856 CHEMBL4640000::US11292781, Compound T92

SMILES [H][C@]12CCc3c(nc(nc3[C@]1(C)C=C(C#N)C(=O)[C@@H]2C)N1CCOCC1)-c1ccccc1F

InChI Key InChIKey=UPNGVHVWXSPSGY-MJECEPGDSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50544856   

TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544856(CHEMBL4640000 | US11292781, Compound T92)
Affinity DataIC50:  138nMAssay Description:Inverse agonist activity at Gal4-fused RORgammat LBD (unknown origin) by reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544856(CHEMBL4640000 | US11292781, Compound T92)
Affinity DataIC50:  164nMAssay Description:The RORγ assay system was purchased from Indigo Biosciences. This nuclear receptor assay utilizes a human cell line that has been engineered to ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Reata Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50544856(CHEMBL4640000 | US11292781, Compound T92)
Affinity DataIC50:  85nMAssay Description:Inverse agonist activity at RORgammat in human CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by reduction in m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed