BDBM50545028 CHEMBL4647112

SMILES O=C1NCc2c(-c3cnc4cc(F)ccn34)ccc(Nc3ccc4c(n3)CNC43CCOCC3)c21

InChI Key InChIKey=JUUPOXCCHOFKNI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50545028   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50545028BDBM50545028(CHEMBL6102496)
Affinity DataIC50: 12nMAssay Description:Inhibition of hypoxia-induced HIF1 activation in human T47D cells after 16 hrs by cell based luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 3(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50545028BDBM50545028(CHEMBL6102496)
Affinity DataIC50: 224nMAssay Description:Agonist activity at human PPARgamma assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed