BDBM50546393 CHEMBL4751083

SMILES CNC(=O)c1nn(C)c2ccc(Nc3nccc(n3)-n3cc(CN(C)C)c(C)n3)cc12

InChI Key InChIKey=IXNQUCOVJRJRGJ-UHFFFAOYSA-N

Data  7 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50546393   

TargetTyrosine-protein kinase SYK(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50546393(CHEMBL4751083)
Affinity DataIC50: 0.310nMAssay Description:Inhibition of recombinant full length SYK (unknown origin) by biochemical Omnia assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50546393(CHEMBL4751083)
Affinity DataIC50: 0.310nMAssay Description:Inhibition of full length recombinant human SYKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50546393(CHEMBL4751083)
Affinity DataIC50: 0.310nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50546393(CHEMBL4751083)
Affinity DataIC50: 0.310nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50546393(CHEMBL4751083)
Affinity DataKd:  73nMAssay Description:Binding affinity to ZAP70 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
LigandPNGBDBM50546393(CHEMBL4751083)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human ERG by plate-based planar patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
LigandPNGBDBM50546393(CHEMBL4751083)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human ERG assessed as tail current by plate-based planar patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
LigandPNGBDBM50546393(CHEMBL4751083)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed