BDBM50546560 CHEMBL4778342

SMILES CN(C[C@@H]1CCCN1)Cc1c(cnc2ncn(-c3cc(O)cc(F)c3)c(=O)c12)-c1cc(C)cc(Cl)c1

InChI Key InChIKey=YBLBKTUFAZAQNI-FQEVSTJZSA-N

Data  5 IC50  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50546560   

TargetCytochrome P450 3A4(Homo sapiens (Human))
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50546560(CHEMBL4778342)
Affinity DataIC50: <1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50546560(CHEMBL4778342)
Affinity DataIC50: <1.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50546560(CHEMBL4778342)
Affinity DataIC50:  2.00E+6nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50546560(CHEMBL4778342)
Affinity DataIC50: <1.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50546560(CHEMBL4778342)
Affinity DataIC50:  3.16E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50546560(CHEMBL4778342)
Affinity DataEC50:  0.501nMAssay Description:Agonist activity at human SST2 expressed in CHOK1 cells assessed as inhibition of NKH477-stimulated intracellular cAMP levelsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSomatostatin receptor type 4(Homo sapiens (Human))
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50546560(CHEMBL4778342)
Affinity DataEC50:  0.501nMAssay Description:Agonist activity at human SST4More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSomatostatin receptor type 5(Homo sapiens (Human))
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50546560(CHEMBL4778342)
Affinity DataEC50: <1.00E+3nMAssay Description:Agonist activity at human SST5More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSomatostatin receptor type 1(Homo sapiens (Human))
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50546560(CHEMBL4778342)
Affinity DataEC50:  316nMAssay Description:Agonist activity at human SST1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSomatostatin receptor type 3(Homo sapiens (Human))
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50546560(CHEMBL4778342)
Affinity DataEC50:  7.90nMAssay Description:Agonist activity at human SST3More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Crinetics Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50546560(CHEMBL4778342)
Affinity DataEC50:  63nMAssay Description:Agonist activity at human N-terminal HA-tagged SST2 expressed in cell assessed as induction of receptor internalization by colorimetric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed