BDBM50546962 CHEMBL4741188::US11247971, Cmpd ID 367

SMILES NS(=O)(=O)c1ccc(Cc2c(CC3CC3)n(nc2-c2ccc(F)c(c2)-c2ccccc2)-c2nc(cs2)C(O)=O)cc1F

InChI Key InChIKey=BKYJCDTWBVQLTK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50546962   

TargetL-lactate dehydrogenase A chain(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50546962(CHEMBL4741188 | US11247971, Cmpd ID 367)
Affinity DataIC50: 23nMAssay Description:Inhibition of recombinant human LDHA using sodium pyruvate as substrate preincubated for 5 mins followed by diaphorase/resazurin addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50546962(CHEMBL4741188 | US11247971, Cmpd ID 367)
Affinity DataIC50: 141nMAssay Description:Inhibition of GS[HiBiT]GS-tagged LDHA (unknown origin) expressed in HEK-293T cells measured after 1 hr by CESTAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50546962(CHEMBL4741188 | US11247971, Cmpd ID 367)
Affinity DataIC50: 465nMAssay Description:Inhibition of LDHA in human A673 cells assessed as decrease in lactate production incubated for 2 hrs by lactate oxidase-coupled fluorescence based a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50546962(CHEMBL4741188 | US11247971, Cmpd ID 367)
Affinity DataIC50: 585nMAssay Description:Inhibition of LDHA in human MIA PaCa-2 cells assessed as decrease in lactate production incubated for 2 hrs by lactate oxidase-coupled fluorescence b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed