BDBM50547305 CHEMBL4761695

SMILES [2H]C([2H])([2H])Oc1cc(F)cc2c(N3CCN(CC3)c3ccccc3F)c(cnc12)C#N

InChI Key InChIKey=ILGOICKJVGZODR-FIBGUPNXSA-N

Data  1 KI  1 IC50  18 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50547305   

TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50547305(CHEMBL4761695)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]nisoxetine from recombinant human Dopamine transporter after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM50547305(CHEMBL4761695)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of mGluR5 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 7(Rattus norvegicus (Rat))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50547305(CHEMBL4761695)
Affinity DataEC50:  990nMAssay Description:Positive allosteric modulation of rat mGlu7 expressed in HEK293 cells co- expressing GIRK assessed as potentiation of L-AP4-induced thallium flux inc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 7(Rattus norvegicus (Rat))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50547305(CHEMBL4761695)
Affinity DataEC50:  1.00E+3nMAssay Description:Positive allosteric modulation of rat mGlu7 expressed in HEK293 cells co- expressing GIRK assessed as potentiation of L-AP4-induced thallium flux inc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50547305(CHEMBL4761695)
Affinity DataIC50:  3.50E+3nMAssay Description:Displacement of [3H]-Pentazocine from human recombinant sigma 1 receptor incubated for 120 mins by scintillation counting analysis relative to contro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50547305(CHEMBL4761695)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of mGlu1 receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50547305(CHEMBL4761695)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of mGlu2 receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50547305(CHEMBL4761695)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of mGlu3 receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))TBA
LigandPNGBDBM50547305(CHEMBL4761695)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of mGlu5 receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50547305(CHEMBL4761695)
Affinity DataEC50: >3.00E+4nMAssay Description:Positive allosteric modulation of mGlu4 receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50547305(CHEMBL4761695)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of mGlu8 receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 7(Rattus norvegicus (Rat))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50547305(CHEMBL4761695)
Affinity DataEC50:  1.60E+3nMAssay Description:Positive allosteric modulation of rat mGluR7More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50547305(CHEMBL4761695)
Affinity DataEC50:  1.60E+3nMAssay Description:Positive allosteric modulation of mGluR4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 7(Homo sapiens (Human))TBA
LigandPNGBDBM50547305(CHEMBL4761695)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of mGluR7 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50547305(CHEMBL4761695)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of mGluR8 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50547305(CHEMBL4761695)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of mGluR1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50547305(CHEMBL4761695)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of mGluR2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50547305(CHEMBL4761695)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of mGluR3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 7(Rattus norvegicus (Rat))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50547305(CHEMBL4761695)
Affinity DataEC50:  1.10E+3nMAssay Description:Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 7(Rattus norvegicus (Rat))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50547305(CHEMBL4761695)
Affinity DataEC50:  1.10E+3nMAssay Description:Positive allosteric modulation of rat mGlu7 receptor expressed in HEK293 cells co-expressing Gai5 assessed as potentiation of L-AP4-induced calcium m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed