BDBM50547886 CHEMBL4764433::US11377438, Example 19

SMILES Cc1cc(C(=O)Nc2ccnc(c2)S(N)(=O)=O)c(nc1C)N1CCCC(F)(F)CC1

InChI Key InChIKey=AJTKXBXYINEDCZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50547886   

TargetSodium channel protein type 10 subunit alpha(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50547886(CHEMBL4764433 | US11377438, Example 19)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human Nav1.8 expressed in HEK293 cells by whole cell patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50547886(CHEMBL4764433 | US11377438, Example 19)
Affinity DataIC50: 1.60nMAssay Description:The following buffers were used for the Qube recordings: External buffer for Nav1.8 Qube recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2022
Entry Details
US Patent