BDBM50548040 CHEMBL4791172

SMILES NC1CC1c1ccc(NC(=O)CCCc2ccc(cc2)C(=O)Nc2ccccc2N)cc1

InChI Key InChIKey=TYTLARZOLKJSJU-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50548040   

TargetLysine-specific histone demethylase 1A(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50548040(CHEMBL4791172)
Affinity DataIC50: 100nMAssay Description:Inhibition of LSD1 (unknown origin) using diMeK4H31-21 as substrate preincubated for 5 mins followed by substrate addition measured for 5 mins by abs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50548040(CHEMBL4791172)
Affinity DataIC50: 140nMAssay Description:Inhibition of HDAC1 (unknown origin) using RHKK(Ac) as substrate incubated for 30 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50548040(CHEMBL4791172)
Affinity DataIC50: 140nMAssay Description:Inhibition of human recombinant HDAC1 (unknown origin) using MAZ1600 as substrate preincubated for 3 hrs followed by substrate addition by multilabel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50548040(CHEMBL4791172)
Affinity DataIC50: 147nMAssay Description:Inhibition of C-terminal His/FLAG-tagged human HDAC1 expressed in Sf9 insect cells using acetylated P53(379-382 residues) (RHKK(Ac)) as substrate inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50548040(CHEMBL4791172)
Affinity DataIC50: 206nMAssay Description:Inhibition of human recombinant C-terminal FLAG-tagged HDAC1 using HDAC as fluorogenic substrate incubated for 30 mins by dual fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50548040(CHEMBL4791172)
Affinity DataIC50: 300nMAssay Description:Inhibition of C-terminal His-tagged LSD1 (unknown origin) expressed in Escherichia coli BL21 (DE3) using ART(mK)QTARKSTGGKAPRKQLAGGK-Biotin as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50548040(CHEMBL4791172)
Affinity DataIC50: 300nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetREST corepressor 1(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50548040(CHEMBL4791172)
Affinity DataIC50: 330nMAssay Description:Inhibition of LSD1/FLAG-tagged CoREST (unknown origin) expressed in HEK293F cells using diMeK4H3(1 to 21 residues) as substrate preincubated for 5 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50548040(CHEMBL4791172)
Affinity DataIC50: 330nMAssay Description:Inhibition of human recombinant LSD1 using histone H3 1-21K4me as substrate incubated for 1 hr by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetREST corepressor 1(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50548040(CHEMBL4791172)
Affinity DataIC50: 330nMAssay Description:Inhibition of N-terminal GST-tagged LSD1 (171 to 852 residues) (unknown origin) expressed in Escherichia coli FLAG-tagged CoREST1 (unknown origin) tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
National Institute of Pharmaceutical Education and Research (NIPER)

Curated by ChEMBL
LigandPNGBDBM50548040(CHEMBL4791172)
Affinity DataIC50: 330nMAssay Description:Inhibition of N-terminal GST tagged LSD1 (residues 171 - 852) (unknown origin) overexpressed in Escherichia coli using ARTK(Me)2QTARKSTGGKAPRKQLAas s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetREST corepressor 1(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50548040(CHEMBL4791172)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of LSD1/FLAG-tagged CoREST (unknown origin) expressed in HEK293F cells using diMeK4H3(1 to 21) as substrate preincubated for 5 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed