BDBM50548083 CHEMBL4748313::US11993603, Example 1

SMILES COCCn1cc(Nc2ncc3cnn(Cc4cccc(NC(=O)C=C)c4)c3n2)cn1

InChI Key InChIKey=BOBFKXIKGHTPJB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50548083   

TargetTyrosine-protein kinase JAK3(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50548083(CHEMBL4748313 | US11993603, Example 1)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human JAK3 expressed in baculovirus expression system using TK-substrate-biotin as substrate preincubated for 5 mins followed by ATP an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50548083(CHEMBL4748313 | US11993603, Example 1)
Affinity DataIC50: 1.40nMAssay Description:In Kinase Reaction, JAK-1, JAK-2 or JAK-3 may transfer γ-phosphoric acid in ATP onto a single tyrosine residue of a peptide substrate; and there...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2024
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Peking Union Medical College

US Patent
LigandPNGBDBM50548083(CHEMBL4748313 | US11993603, Example 1)
Affinity DataIC50: 747nMAssay Description:In Kinase Reaction, JAK-1, JAK-2 or JAK-3 may transfer γ-phosphoric acid in ATP onto a single tyrosine residue of a peptide substrate; and there...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2024
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Peking Union Medical College

US Patent
LigandPNGBDBM50548083(CHEMBL4748313 | US11993603, Example 1)
Affinity DataIC50: 1.05E+3nMAssay Description:In Kinase Reaction, JAK-1, JAK-2 or JAK-3 may transfer γ-phosphoric acid in ATP onto a single tyrosine residue of a peptide substrate; and there...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2024
Entry Details
US Patent