BDBM50548531 CHEMBL4747201

SMILES COc1ccc(-c2ccc3C(=O)OCc3c2)n2nc(nc12)C1(CC1)C(=O)OCC(C)C

InChI Key InChIKey=LUUUHUYQTLUIDG-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50548531   

LigandPNGBDBM50548531(CHEMBL4747201)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of human PDE4D catalytic domain using cAMP and FAM-conjugated cAMP by IMAP FRET progressive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM50548531(CHEMBL4747201)
Affinity DataIC50:  6nMAssay Description:Inhibition of PDE4D in human PBMC assessed as reduction in lipopolysaccharide-induced TNFalpha production pre-incubated for 30 mins before LPS stimul...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM50548531(CHEMBL4747201)
Affinity DataIC50:  3nMAssay Description:Inhibition of human PDE4C catalytic domain using cAMP and FAM-conjugated cAMP by IMAP FRET progressive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50548531(CHEMBL4747201)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human PDE4B catalytic domain using cAMP and FAM-conjugated cAMP by IMAP FRET progressive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM50548531(CHEMBL4747201)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human PDE4A catalytic domain using cAMP and FAM-conjugated cAMP by IMAP FRET progressive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed