BDBM50548603 CHEMBL4761275

SMILES Nc1nc(nn1C(=O)c1ccc(NC(=O)c2ccccc2)cc1)-c1ccccn1

InChI Key InChIKey=JZQYZQOGVYSKNL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50548603   

TargetCoagulation factor XII(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50548603(CHEMBL4761275)
Affinity DataIC50: 109nMAssay Description:Inhibition of human FXIIa (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCoagulation factor XII(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50548603(CHEMBL4761275)
Affinity DataIC50: 109nMAssay Description:Inhibition of human coagulation factor XIIA using Boc-Gln-Gly-Arg-AMC as fluorogenic substrate measured at 1 min interval for 1 hr by fluorometric as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50548603(CHEMBL4761275)
Affinity DataIC50: 163nMAssay Description:Inhibition of FXIIa (unknown origin) using H-D-Pro-Phe-Arg-pNA as substrate incubated for 20 mins followed by substrate addition by spectrophotometri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetChymotrypsinogen B2(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50548603(CHEMBL4761275)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of Chymotrypsin (unknown origin) using N-Suc-Ala-Ala-Pro-Phe-pNA as chromogenic substrate incubated for 20 mins followed by substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPlasminogen(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50548603(CHEMBL4761275)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of plasmin (unknown origin) using PyroGlu-Phe-Lys-pNA.HCl as chromogenic substrate incubated for 20 mins followed by substrate addition by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCoagulation factor X(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50548603(CHEMBL4761275)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of FXa (unknown origin) using Z-D-Arg-Gly-Arg-pNA.2HCl as chromogenic substrate incubated for 20 mins followed by substrate addition by sp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCoagulation factor X(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50548603(CHEMBL4761275)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human coagulation factor Xa using Boc-Ile-Glu-Gly-Arg-AMC as fluorogenic substrate measured at 1 min interval for 1 hr by fluorometric ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50548603(CHEMBL4761275)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of trypsin (unknown origin) using Bz-lle-Glu(gamma-OR)-Gly-Arg-pNA.HCl as chromogenic substrate incubated for 20 mins followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTissue-type plasminogen activator(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50548603(CHEMBL4761275)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of tPA (unknown origin) using H-D-lle-Pro-Arg-pNA-2HCl as chromogenic substrate incubated for 20 mins followed by substrate addition by sp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProthrombin(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50548603(CHEMBL4761275)
Affinity DataIC50: 1.57E+4nMAssay Description:Inhibition of thrombin (unknown origin) using H-D-Phe-Pip-Arg-pNA-2HCl as substrate incubated for 20 mins followed by substrate addition by spectroph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50548603(CHEMBL4761275)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of FXIa (unknown origin) using p-Glu-Pro-Arg-pNA.HCl as chromogenic substrate incubated for 20 mins followed by substrate addition by spec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPlasma kallikrein(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50548603(CHEMBL4761275)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of PKal (unknown origin) using H-D-Pro-Phe-Arg-pNA-2HCl as substrate incubated for 20 mins followed by substrate addition by spectrophotom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed