BDBM50548856 CHEMBL4745057::US20230365568, Compound 35

SMILES CCCn1c2nn(CN(C)C3CC3)c(=S)n2c2ccccc2c1=O

InChI Key InChIKey=NJIIJHDNOJRNIC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50548856   

TargetSerine/threonine-protein kinase PLK1(Human)
National Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50548856(CHEMBL4745057 | US20230365568, Compound 35)
Affinity DataIC50: 1.63E+3nMAssay Description:Inhibition of biotin-Ahx-CETFDPPLHSpTAI-NH2 binding to recombinant human full-length HA-EGFP-tagged Plk1 PBD expressed in HEK293A cells preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
National Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50548856(CHEMBL4745057 | US20230365568, Compound 35)
Affinity DataIC50: 1.63E+3nMAssay Description:An ELISA-based PBD-binding inhibition assay was performed essentially as described previously. Briefly, a biotinylated PBIP1 p-T78 peptide (i.e., Bio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2024
Entry Details
US Patent