BDBM50548875 CHEMBL4784212::US20230365568, Compound 54

SMILES CCCn1c2n[nH]c(=S)n2c2ccc(Cl)cc2c1=O

InChI Key InChIKey=HXJVZTMGWRDKKD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50548875   

TargetSerine/threonine-protein kinase PLK1(Human)
National Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50548875(CHEMBL4784212 | US20230365568, Compound 54)
Affinity DataIC50: 1.77E+3nMAssay Description:Inhibition of biotin-Ahx-CETFDPPLHSpTAI-NH2 binding to recombinant human full-length HA-EGFP-tagged Plk1 PBD expressed in HEK293A cells preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
National Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50548875(CHEMBL4784212 | US20230365568, Compound 54)
Affinity DataIC50: 1.77E+3nMAssay Description:An ELISA-based PBD-binding inhibition assay was performed essentially as described previously. Briefly, a biotinylated PBIP1 p-T78 peptide (i.e., Bio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2024
Entry Details
US Patent