BDBM50549840 CHEMBL4800674

SMILES Cc1nc(NC(=O)NCCOCC2CC2)sc1C#Cc1ccnc(F)c1

InChI Key InChIKey=KSLXFOOQISQSAJ-UHFFFAOYSA-N

Data  1 KI  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50549840   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Vertex Pharmaceuticals

Curated by ChEMBL

LigandBDBM50549840(CHEMBL4800674)Copy SMILESCopy InChI

Affinity DataKi:  6nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate measured after 15 mins in presence of [33P]-ATP by liquid scintillation counting met...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Vertex Pharmaceuticals

Curated by ChEMBL

LigandBDBM50549840(CHEMBL4800674)Copy SMILESCopy InChI

Affinity DataIC50:  490nMAssay Description:Inhibition of PI3Kgamma in human THP-1 cells assessed as reduction in Akt phosphorylation at Ser473 residueMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI
Copy reaction URL