BDBM50550225 CHEMBL4764510

SMILES Cc1ccccc1NC(=O)N1C(CC(=O)NCCC(O)=O)CC1=O

InChI Key InChIKey=LOXDBHIFADBELN-UHFFFAOYSA-N

Data  9 IC50  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50550225   Sort by

TargetIntegrin alpha-5/beta-1(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50550225(CHEMBL4764510)
Affinity DataIC50: 36nMAssay Description:Inhibition of fibronectin binding to alpha5beta1 isolated from human K562 cells incubated for 1 hr by scintillation-proximity assay based competitive...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50550225(CHEMBL4764510)
Affinity DataEC50:  187nMAssay Description:Agonist activity at alphaVbeta3 in human SK-MEL-24 cells assessed as increase in cell adhesion to fibronectin pre-incubated for 30 mins before fibron...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetIntegrin alpha-V/beta-5(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50550225(CHEMBL4764510)
Affinity DataEC50:  670nMAssay Description:Agonist activity at alphaVbeta5 in human MCF7 cells assessed as increase in cell adhesion to fibrinogen pre-incubated for 30 mins before fibrinogen a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50550225(CHEMBL4764510)
Affinity DataIC50: 44nMAssay Description:Antagonist activity at alphaVbeta6 in human HT-29 cells assessed as reduction in cell adhesion to fibronectin pre-incubated for 30 mins before fibron...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetIntegrin alpha-5/beta-1(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50550225(CHEMBL4764510)
Affinity DataEC50:  49nMAssay Description:Agonist activity at alpha5beta1 in human K562 cells assessed as increase in cell adhesion to fibronectin pre-incubated for 30 mins before fibronectin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50550225(CHEMBL4764510)
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at alpha2bbeta3 in human HEL cells assessed as increase in cell adhesion to fibrinogen pre-incubated for 30 mins before fibrinogen a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50550225(CHEMBL4764510)
Affinity DataIC50: 5.00E+3nMAssay Description:Antagonist activity at alpha2bbeta3 in human HEL cells assessed as reduction in cell adhesion to fibrinogen pre-incubated for 30 mins before fibrinog...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetIntegrin alpha-4/beta-1(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50550225(CHEMBL4764510)
Affinity DataIC50: 17nMAssay Description:Antagonist activity at alpha4beta1 in human Jurkat E6.1 cells assessed as reduction in cell adhesion to VCAM1 pre-incubated for 30 mins before VCAM1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50550225(CHEMBL4764510)
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at alphaLbeta2 in human Jurkat E6.1 cells assessed as increase in cell adhesion to ICAM1 pre-incubated for 30 mins before ICAM1 and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50550225(CHEMBL4764510)
Affinity DataIC50: 5.00E+3nMAssay Description:Antagonist activity at alphaLbeta2 in human Jurkat E6.1 cells assessed as reduction in cell adhesion to ICAM1 pre-incubated for 30 mins before ICAM1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50550225(CHEMBL4764510)
Affinity DataIC50: 116nMAssay Description:Inhibition of fibronectin binding to human recombinant alphaVbeta3 expressed in HEK293 cells incubated for 1 hr by scintillation-proximity assay base...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetIntegrin alpha-V/beta-5(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50550225(CHEMBL4764510)
Affinity DataIC50: 634nMAssay Description:Inhibition of fibrinogen binding to alphaVbeta5 isolated form human mCf7 cells incubated for 1 hr by scintillation-proximity assay based competitive ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50550225(CHEMBL4764510)
Affinity DataIC50: 23nMAssay Description:Inhibition of fibronectin binding to alphaVbeta6 isolated form human HT-29 cells incubated for 1 hr by scintillation-proximity assay based competitiv...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetIntegrin alpha-4/beta-1(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM50550225(CHEMBL4764510)
Affinity DataIC50: 12nMAssay Description:Inhibition of fibronectin binding to alpha4bbeta1 isolated from human Jurkat E6.1 cells incubated for 1 hr by scintillation-proximity assay based com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed