BDBM50550657 CHEMBL4792737
SMILES COc1ccc2Sc3c(Cc2c1)cccc3-c1cc(=O)cc(o1)N1CCOCC1
InChI Key InChIKey=CIZOSCVUGRBXEZ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 12 hits for monomerid = 50550657
Affinity DataKi: 0.5nMAssay Description:Inhibition of full length recombinant FLAG-tagged human ATM assessed as decrease in p53 S15 phosphorylation using full length myc-tagged p53 as subst...More data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Inhibition of rat neutrophil 5- Lipoxygenase (5-LO)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Charles River
Curated by ChEMBL
Charles River
Curated by ChEMBL
Affinity DataKi: 15nMAssay Description:Inhibition of full length recombinant GST-tagged human VPS34 expressed in baculovirus expression system using PI/PS as substrate incubated for 60 min...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Charles River
Curated by ChEMBL
Charles River
Curated by ChEMBL
Affinity DataKi: 15nMAssay Description:Inhibition of rat neutrophil 5- Lipoxygenase (5-LO), (at a concentration of 0.2 nM ),More data for this Ligand-Target Pair
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Chdi Management/Chdi Foundation
Curated by ChEMBL
Chdi Management/Chdi Foundation
Curated by ChEMBL
Affinity DataIC50: 285nMAssay Description:Inhibition of DNA-PK isolated from human HeLa cells assessed as reduction in p53 Ser15 phosphorylation by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of ATM in human U2OS cells assessed as reduction in etoposide-stimulated KAP1 phosphorylation incubated for 60 mins by immunoreactivity as...More data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of rat neutrophil 5- Lipoxygenase (5-LO)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Charles River
Curated by ChEMBL
Charles River
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inhibition of recombinant full-length human VPS34 incubated for 60 mins by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Chdi Management/Chdi Foundation
Curated by ChEMBL
Chdi Management/Chdi Foundation
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of ATR in human HeLa cells incubated for 4 hrsMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Charles River
Curated by ChEMBL
Charles River
Curated by ChEMBL
Affinity DataKd: 5.10nMAssay Description:Binding affinity to human Vps34 expressed in mammalian expression systemMore data for this Ligand-Target Pair
Affinity DataIC50: 910nMAssay Description:Inhibition of ATM in human MCF7 cells assessed as reduction in etoposide-stimulated KAP1 phosphorylation incubated for 1 hr by ICW assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant full-length human FLAG-tagged ATM assessed as reduction in p53 S15 phosphorylation incubated for 30 mins by ELISAMore data for this Ligand-Target Pair