BDBM50551132 CHEMBL4777038

SMILES Cc1ccc(NC(=O)c2ncn(CC(=O)NCCn3ccc4c(N)ncnc34)n2)cc1C

InChI Key InChIKey=RXUMEIKBRRTYMR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50551132   

TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
University Of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50551132(CHEMBL4777038)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of recombinant human DNMT1 using poly(dl-dC) as substrate by hotspot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Homo sapiens (Human))
University Of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50551132(CHEMBL4777038)
Affinity DataIC50:  1.09E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged DOT1L (1 to 420 residues) expressed in Escherichia coli BL21 (DE3) using histone as substrate i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed