BDBM50552703 CHEMBL4758121

SMILES OC1(CCN(CC1)c1cc2n(ncc2cc1Cl)-c1cnn(c1)C1CC1)c1cncs1

InChI Key InChIKey=PMXDWGJYPKMTRX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50552703   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50552703(CHEMBL4758121 | US12319671, Example 6.54)
Affinity DataIC50: 97.5nMAssay Description:Assays were performed in the presence of 134 μM ATP (Km ATP). Upon completion, the assay was stopped, and phosphorylated substrate detected with a te...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2025
Entry Details
US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50552703(CHEMBL4758121 | US12319671, Example 6.54)
Affinity DataIC50: 98nMAssay Description:Inhibition of GST-tagged truncated human LRRK2 G2019S mutant using fluorescein labeled LRRKtide peptide as substrate preincubated for 15 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed