BDBM50552704 CHEMBL4782722

SMILES CO[C@H]1COC[C@H]1N1CCN(CC1)c1cc2n(ncc2cc1Cl)-c1cnn(c1)C12CC(C1)C2

InChI Key InChIKey=ILQWZLPDBJRSTL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50552704   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50552704(CHEMBL4782722 | US12319671, Example 10.1)
Affinity DataIC50: 104nMAssay Description:Assays were performed in the presence of 134 μM ATP (Km ATP). Upon completion, the assay was stopped, and phosphorylated substrate detected with a te...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2025
Entry Details
US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50552704(CHEMBL4782722 | US12319671, Example 10.1)
Affinity DataIC50: 104nMAssay Description:Inhibition of GST-tagged truncated human LRRK2 G2019S mutant using fluorescein labeled LRRKtide peptide as substrate preincubated for 15 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed