BDBM50552706 CHEMBL4797678

SMILES Cc1cc2cnn(-c3cnn(c3)C34CC(C3)C4)c2cc1N1CCN(CC1)[C@@H]1COC[C@@H]1O

InChI Key InChIKey=FWNRNKYEHVWGDL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50552706   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50552706(CHEMBL4797678 | US12319671, Example 16.2)
Affinity DataIC50: 259nMAssay Description:Inhibition of GST-tagged truncated human LRRK2 G2019S mutant using fluorescein labeled LRRKtide peptide as substrate preincubated for 15 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50552706(CHEMBL4797678 | US12319671, Example 16.2)
Affinity DataIC50: 259nMAssay Description:Assays were performed in the presence of 134 μM ATP (Km ATP). Upon completion, the assay was stopped, and phosphorylated substrate detected with a te...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2025
Entry Details
US Patent