BDBM50552746 CHEMBL4759259::US20240067660, Compound 28

SMILES [H][C@]12COCCN1CCN(C[C@@H]1N3CC[C@H]3CN3C[C@@]4(CCCc5cc(Cl)ccc45)COc4ccc(cc34)C(=O)NS(=O)(=O)[C@H](C)[C@@H](C)C\C=C1/F)C2

InChI Key InChIKey=CEWGCPJPJBRCRQ-ZQZULIRTSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50552746   

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50552746(CHEMBL4759259 | US20240067660, Compound 28)
Affinity DataKi:  0.0900nMAssay Description:The following assay and stock buffers were prepared for use in the assay: (a) Stock buffer: 10 mM Tris-HCl, pH=7.5+150 mM NaCl, filtered, sterilized,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50552746(CHEMBL4759259 | US20240067660, Compound 28)
Affinity DataKi:  0.0900nMAssay Description:Inhibition of Terbium-labeled BIM BH3 peptide binding to MCL1 (unknown origin) incubated for 60 mins by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed