BDBM50553486 CHEMBL4782409
SMILES CN1CC[C@H]([C@@H]1CO)c1c(OP(O)(O)=O)cc(O)c2c1oc(cc2=O)-c1ccc(cc1Cl)C(F)(F)F
InChI Key InChIKey=WLTRIWCDHOZNRP-OCCSQVGLSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 9 hits for monomerid = 50553486
Affinity DataKi: 1.70nMAssay Description:Inhibition of N-terminal His6-tagged thrombin cleavage site-fused human CDK9 (M1 to F372 residues)/cyclin-T1 (M1 to K726 residues) expressed in bacul...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D1(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataKi: 2.90nMAssay Description:Inhibition of N-terminal His6-tagged thrombin cleavage site-fused human CDK6 (M1 to A326 residues)/cyclin D1 (Q4 to I295 residues) expressed in bacul...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataKi: 4nMAssay Description:Inhibition of N-terminal His6-tagged thrombin cleavage site-fused human CDK4 (S4 to E303 residues)/cyclin D1 (Q4 to I295 residues) expressed in bacul...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 210nMAssay Description:Inhibition of N-terminal His6-tagged thrombin cleavage site-fused human CDK6 (M1 to A326 residues)/cyclin D3 (M1 to L292 residues) expressed in bacul...More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of N-terminal His6-tagged thrombin cleavage site-fused human CDK8 (M1 to Y463 residues)/cyclin D3 (M1 to S283 residues) expressed in bacul...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Inhibition of N-terminal His6-tagged thrombin cleavage site-fused human CDK4 (S4 to E303 residues)/cyclin D1 (Q4 to I295 residues) expressed in bacul...More data for this Ligand-Target Pair
Affinity DataIC50: 180nMAssay Description:Inhibition of N-terminal His6-tagged thrombin cleavage site-fused human CDK2 (M1 to L298 residues)/cyclin A2 (M1 to L432 residues) expressed in bacul...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of N-terminal His6-tagged thrombin cleavage site-fused human CDK1 (M1 to M297 residues)/cyclin B1 (M1 to V433 residues) expressed in bacul...More data for this Ligand-Target Pair
Affinity DataIC50: 210nMAssay Description:Inhibition of N-terminal His6-tagged thrombin cleavage site-fused human CDK5 (M1 to P292 residues)/p35 (M1 to R307 residues) expressed in baculovirus...More data for this Ligand-Target Pair