BDBM50553871 CHEMBL1392132

SMILES COc1ccc(cc1)-c1cc2ccc(O)cc2oc1=O

InChI Key InChIKey=VGYCHSOZFBOOKO-UHFFFAOYSA-N

Data  1 KI  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50553871   

TargetMacrophage migration inhibitory factor(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50553871(CHEMBL1392132)
Affinity DataKi:  370nMAssay Description:Inhibition of C-terminal His-tagged recombinant human MIF expressed in Escherichia coli BL21 (DE3) using 4-HPP as substrate preincubated for 10 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetMacrophage migration inhibitory factor(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50553871(CHEMBL1392132)
Affinity DataKd:  390nMAssay Description:Binding affinity to C-terminal His-tagged recombinant human MIF expressed in Escherichia coli BL21 (DE3) at 100 nM by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetMacrophage migration inhibitory factor(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50553871(CHEMBL1392132)
Affinity DataIC50: 560nMAssay Description:Inhibition of C-terminal His-tagged recombinant human MIF expressed in Escherichia coli BL21 (DE3) using 4-HPP as substrate preincubated for 10 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50553871(CHEMBL1392132)
Affinity DataKd:  3.90E+3nMAssay Description:Binding affinity to human SIRT3 (102 to 399 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50553871(CHEMBL1392132)
Affinity DataIC50: 7.58E+4nMAssay Description:Activation of human SIRT3 (unknown origin) deacetylation activity using fluorogenic substrate measured upto 120 mins by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed