BDBM50554287 CHEMBL4745237

SMILES CC(C)C[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(C)C)[C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(N)=O

InChI Key InChIKey=PYDPWXBBGPHHHN-UHFFFAOYSA-N

Data  2 KI  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50554287   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Tokyo Institute of Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50554287BDBM50554287(CHEMBL4745237)
Affinity DataKi:  237nMAssay Description:Competitive binding affinity to human MDM2 assessed as displacement of p1-LC4f peptide by fluorescence polarization competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Tokyo Institute of Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50554287BDBM50554287(CHEMBL4745237)
Affinity DataKd:  410nMAssay Description:Binding affinity to recombinant human MDM2 (25 to 111 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant by fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Tokyo Institute of Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50554287BDBM50554287(CHEMBL4745237)
Affinity DataKi:  461nMAssay Description:Competitive binding affinity to human MDM2 assessed as displacement of p3-BPf peptide by fluorescence polarization competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed