BDBM50556935 CHEMBL4764925

SMILES O=C([C@H]1CCN1S(=O)(=O)c2c(F)c(F)c(F)c(F)c2F)N(Cc4ccc(C3CCCCC3)cn4)c6ccc5c(=O)[nH]cnc5c6

InChI Key InChIKey=XAGZDGDLYLQXQM-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50556935   

TargetSignal transducer and activator of transcription 3(Human)
Cedars-Sinai Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50556935BDBM50556935(CHEMBL4764925)
Affinity DataIC50: 870nMAssay Description:Inhibition of C-terminal 6His-tagged recombinant human STAT3 (127 to 711 residues) DNA-binding activity transfected in v-Src transformed mouse NIH3T3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Cedars-Sinai Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50556935BDBM50556935(CHEMBL4764925)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of C-terminal 6His-tagged recombinant human STAT3 (127 to 711 residues) DNA-binding activity transfected in v-Src transformed mouse NIH3T3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Cedars-Sinai Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50556935BDBM50556935(CHEMBL4764925)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of C-terminal 6His-tagged recombinant human STAT3 (127 to 711 residues) DNA-binding activity transfected in v-Src transformed mouse NIH3T3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Cedars-Sinai Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50556935BDBM50556935(CHEMBL4764925)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of recombinant wild type tyrosine phosphorylated C-terminal 6His tagged human STAT3 (127 to 711 residues) DNA-binding activity transfected...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Cedars-Sinai Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50556935BDBM50556935(CHEMBL4764925)
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of recombinant wild type tyrosine phosphorylated C-terminal 6His tagged human STAT3 C542S mutant (127 to 711 residues) DNA-binding activit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Cedars-Sinai Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50556935BDBM50556935(CHEMBL4764925)
Affinity DataIC50: 7.60E+3nMAssay Description:Inhibition of recombinant wild type tyrosine phosphorylated C-terminal 6His tagged human STAT3 C426A mutant (127 to 711 residues) DNA-binding activit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Cedars-Sinai Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50556935BDBM50556935(CHEMBL4764925)
Affinity DataIC50: 8.20E+3nMAssay Description:Inhibition of recombinant wild type tyrosine phosphorylated C-terminal 6His tagged human STAT3 C328A mutant (127 to 711 residues) DNA-binding activit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Cedars-Sinai Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50556935BDBM50556935(CHEMBL4764925)
Affinity DataIC50: 4.70E+4nMAssay Description:Inhibition of recombinant wild type tyrosine phosphorylated C-terminal 6His tagged human STAT3 C468A mutant (127 to 711 residues) DNA-binding activit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Cedars-Sinai Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50556935BDBM50556935(CHEMBL4764925)
Affinity DataIC50: 6.00E+5nMAssay Description:Displacement of 5-carboxyfluorescein GpYLPQTV-NH2 probe from C-terminal 6His-tagged recombinant human STAT3 (127 to 711 residues) SH2 domain extracte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Cedars-Sinai Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50556935BDBM50556935(CHEMBL4764925)
Affinity DataIC50: 6.00E+5nMAssay Description:Displacement of 5-carboxyfluorescein GpYLPQTV-NH2 probe from C-terminal 6His-tagged recombinant human STAT3 (127 to 711 residues) SH2 domain extracte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Cedars-Sinai Medical Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50556935BDBM50556935(CHEMBL4764925)
Affinity DataIC50: 6.00E+5nMAssay Description:Displacement of 5-carboxyfluorescein GpYLPQTV-NH2 probe from C-terminal 6His-tagged recombinant human STAT3 (127 to 711 residues) SH2 domain extracte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed