BDBM50557482 CHEMBL4747591
SMILES Cn1cc(Nc2nccc(n2)N2CC3CCC(C2)N3C(=O)[C@@H]2CC2(F)F)cn1
InChI Key InChIKey=BUWBRTXGQRBBHG-UHFFFAOYSA-N
Data 17 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 17 hits for monomerid = 50557482
Affinity DataIC50: 5.20nMAssay Description:Inhibition of TYK2 (unknown origin) by caliper technologyMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of JAK1 JH1 domain (unknown origin) using FITC-Ahx-KKSRGDYMTMQIG-NH2 peptide as substrate incubated for 60 mins in the presence of ATP by ...More data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant human JAK1 assessed as phosphorylation level in presence of 1 mM ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of JAK 1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of recombinant human Tyk2 expressed in sf21 baculovirus expression system assessed as phosphorylation level in presence of 1 mM ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Inhibition of JAK2 JH1 domain (unknown origin) using Carboxyfluorescein-Ahx-GGEEEEYFELVKKKK peptide as substrate incubated for 60 mins in the presenc...More data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 1-alpha/beta(Human)
Galapagos NV
Curated by ChEMBL
Galapagos NV
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of IFNalpha-induced STAT1 phosphorylation in human PBMC cells incubated for 4 daysMore data for this Ligand-Target Pair
Affinity DataIC50: 54nMAssay Description:Inhibition of JAK1/JAK3 in human M07E cells assessed as reduction of IL-15 stimulated STAT phosphorylation preincubated for 30 mins followed by IL-15...More data for this Ligand-Target Pair
Affinity DataIC50: 65nMAssay Description:Inhibition of JAK1/JAK3 in human blood assessed as reduction of IL-2 stimulated STAT phosphorylation preincubated for 30 mins followed by IL-2 stimul...More data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK1(Human)
Novartis
Curated by ChEMBL
Novartis
Curated by ChEMBL
Affinity DataIC50: 73nMAssay Description:Inhibition of JAK1/TYK2 in human M07E cells assessed as reduction of IFN alpha stimulated STAT phosphorylation preincubated for 30 mins followed by I...More data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 1-alpha/beta(Human)
Galapagos NV
Curated by ChEMBL
Galapagos NV
Curated by ChEMBL
Affinity DataIC50: 74nMAssay Description:Inhibition of IL-6 induced STAT1 phosphorylation in human whole blood preincubated with compound for 30 mins followed by IL-6 induction and measured ...More data for this Ligand-Target Pair
Affinity DataIC50: 77nMAssay Description:Inhibition of recombinant human JAK2 assessed as phosphorylation level in presence of 1 mM ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 77nMAssay Description:Inhibition of JAK 2 (unknown origin)More data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 1-alpha/beta(Human)
Galapagos NV
Curated by ChEMBL
Galapagos NV
Curated by ChEMBL
Affinity DataIC50: 85nMAssay Description:Inhibition of IFN-alpha induced STAT1 phosphorylation in human whole blood preincubated with compound for 30 mins followed by IFN-alpha induction and...More data for this Ligand-Target Pair
TargetSignal transducer and activator of transcription 1-alpha/beta(Human)
Galapagos NV
Curated by ChEMBL
Galapagos NV
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of GM-CSF induced STAT1 phosphorylation in human PBMC cells incubated for 4 daysMore data for this Ligand-Target Pair
Affinity DataIC50: 1.54E+3nMAssay Description:Inhibition of JAK3 JH1 domain (unknown origin) using Carboxyfluorescein-Ahx-GGEEEEYFELVKKKK peptide as substrate incubated for 60 mins in the presenc...More data for this Ligand-Target Pair
Affinity DataIC50: 6.49E+3nMAssay Description:Inhibition of recombinant human JAK3 assessed as phosphorylation level in presence of 1 mM ATPMore data for this Ligand-Target Pair