BDBM50557728 CHEMBL4761315

SMILES Cc1cncc2sc(NC(=O)[C@@H]3C[C@H]3c3ccccc3)cc12

InChI Key InChIKey=FSBFXIDBSJPZHK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50557728   

TargetRho-associated protein kinase 2(Human)
Alcon

US Patent
LigandPNGBDBM50557728(CHEMBL4761315 | US12459956, Compound 13)
Affinity DataIC50: 18nMAssay Description:The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2026
Entry Details US Patent

TargetRho-associated protein kinase 2(Human)
Alcon

US Patent
LigandPNGBDBM50557728(CHEMBL4761315 | US12459956, Compound 13)
Affinity DataIC50: 18nMAssay Description:Inhibition of ROCK2 (unknown origin) using KRRRLSSLRA as substrate incubated for 75 mins in presence of ATP and DTT by Kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed