BDBM50559446 CHEMBL4779321

SMILES Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCNC(=O)COc2cnc3c(ncnc3c2)C2CCN(CC2)C(=O)c2ccc(OC(F)(F)F)cc2)C(C)(C)C)cc1

InChI Key InChIKey=GHTMDZMLIMLRHJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50559446   

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50559446(CHEMBL4779321)
Affinity DataIC50: 307nMAssay Description:Inhibition of VHL (unknown origin) assessed as phosphorylated peptide substrate incubated for 60 mins by TR-FRET based biochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 7(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50559446(CHEMBL4779321)
Affinity DataIC50: 1.23E+3nMAssay Description:Inhibition of recombinant human GST-tagged ERK5 (1 to 398 assessed as phosphorylated peptide substrate incubated for 60 mins by TR-FRET based biochem...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50559446(CHEMBL4779321)
Affinity DataIC50: 4.31E+3nMAssay Description:Inhibition of NanoLuc-tagged VHL in HEK293 cells incubated for 2 hrs by NanoBRET live cell assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed