BDBM50559678 CHEMBL4763467

SMILES CCC(Nc1nnc(o1)-c1ccc(OC)cc1)[C@H]1CC[C@H](CC1)c1ccnc2ccc(cc12)C(F)(F)F

InChI Key InChIKey=SUDVIJKGHSMHQM-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50559678   

TargetIndoleamine 2,3-dioxygenase 1(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50559678(CHEMBL4763467)
Affinity DataIC50: 3nMAssay Description:Inhibition of IDO1 in recombinant IFN-gamma induced human HeLa cells incubated for 18 hrs by fluorescence microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Mouse)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50559678(CHEMBL4763467)
Affinity DataIC50: 6nMAssay Description:Inhibition of IDO1 in recombinant IFN-gamma induced mouse M109 cells incubated for 18 hrs by fluorescence microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50559678(CHEMBL4763467)
Affinity DataIC50: 50nMAssay Description:Inhibition of IDO1 in IFN-gamma/LPS induced human whole blood assessed as tryptophan/kynurenine level measured after 18 hrs by RapidFire mass spectro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetNuclear receptor subfamily 1 group I member 2(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50559678(CHEMBL4763467)
Affinity DataEC50:  1.06E+3nMAssay Description:Transactivation of PXR (unknown origin) assessed as CYP450 inductionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed