BDBM50559715 CHEMBL4781238

SMILES [H][C@]12CC(=O)C=C[C@]1(CCN2C)c1ccc(OC)c(OC)c1

InChI Key InChIKey=HDNHBCSWFYFPAN-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50559715   

TargetSodium-dependent serotonin transporter(Human)
Sensorium Therapeutics

US Patent
LigandPNGBDBM50559715(CHEMBL4781238 | US20250059156, Compound Mesembreno...)
Affinity DataKi:  27nMAssay Description:SERT inhibition was measured using a Neruotransmitter Transportation Fluorescence assay. Briefly, stable 5HHH cells were prepared in a 384 microwell ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetSodium-dependent serotonin transporter(Human)
Sensorium Therapeutics

US Patent
LigandPNGBDBM50559715(CHEMBL4781238 | US20250059156, Compound Mesembreno...)
Affinity DataKi:  27nMAssay Description:Displacement of [3H]imipramine from recombinant human 5'-HT transporter expressed in CHO cells incubated for 60 mins by Scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Sensorium Therapeutics

US Patent
LigandPNGBDBM50559715(CHEMBL4781238 | US20250059156, Compound Mesembreno...)
Affinity DataIC50: 470nMAssay Description:1) Dilute 20 μM FAM-Cyclic-3′, 5′-AMP stock 100-fold with PDE buffer to make a 200 nM solution. Make only sufficient quantity needed for the assay; s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2025
Entry Details
US Patent

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Sensorium Therapeutics

US Patent
LigandPNGBDBM50559715(CHEMBL4781238 | US20250059156, Compound Mesembreno...)
Affinity DataIC50: 470nMAssay Description:Inhibition of recombinant human PDE4B expressed in baculovirus infected Sf9 cells using cAMP as substrate after 30 min by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed