BDBM50561735 CHEMBL4793879

SMILES [H][C@]12CC[C@]([H])(CN(C1)c1cnnc(OC)c1)[C@H]2Nc1nc2[C@@H](CCCn2n1)Oc1cc(F)cc(Cl)c1

InChI Key InChIKey=YXVXJOUZYSITLN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50561735   

TargetPresenilin-1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50561735(CHEMBL4793879 | US12195470, Example 8)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of human gamma secretase assessed as reduction in Abeta42 productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein [1-42](Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM50561735(CHEMBL4793879 | US12195470, Example 8)
Affinity DataIC50: 34.1nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μL in 96-w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent