BDBM50561912 CHEMBL4798823

SMILES CCCCCCCCCCCCCC(=S)NCCCC[C@H](NC(=O)CCOCCOCCNc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12)C(=O)Nc1ccccc1

InChI Key InChIKey=GIYJZXALTTVTFT-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50561912   

TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Cornell University

Curated by ChEMBL
LigandPNGBDBM50561912(CHEMBL4798823)
Affinity DataIC50: 69nMAssay Description:Inhibition of human SIRT2 deacetylation activity using H3K9Ac as substrate preincubated for 15 mins in presence of NAD+ by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Cornell University

Curated by ChEMBL
LigandPNGBDBM50561912(CHEMBL4798823)
Affinity DataIC50: 120nMAssay Description:Inhibition of human SIRT2 deacetylation activity using H3K9Ac as substrate in presence of NAD+ by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Cornell University

Curated by ChEMBL
LigandPNGBDBM50561912(CHEMBL4798823)
Affinity DataIC50: 170nMAssay Description:Inhibition of human SIRT2 defatty-acylation activity using peptide substrate preincubated in presence of NAD+ followed by substrate addition by HPLC ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Cornell University

Curated by ChEMBL
LigandPNGBDBM50561912(CHEMBL4798823)
Affinity DataIC50: 3.70E+4nMAssay Description:Inhibition of human SIRT1 deacetylation activity using H3K9Ac as substrate preincubated for 15 mins in presence of NAD+ followed by substrate additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-5, mitochondrial(Human)
Cornell University

Curated by ChEMBL
LigandPNGBDBM50561912(CHEMBL4798823)
Affinity DataIC50: 8.30E+4nMAssay Description:Inhibition of human SIRT5 deacetylation activity using H3K9Ac as substrate preincubated for 15 mins in presence of NAD+ followed by substrate additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
Cornell University

Curated by ChEMBL
LigandPNGBDBM50561912(CHEMBL4798823)
Affinity DataIC50: 8.30E+4nMAssay Description:Inhibition of human SIRT6 deacetylation activity using H3K9Ac as substrate preincubated for 15 mins in presence of NAD+ followed by substrate additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Cornell University

Curated by ChEMBL
LigandPNGBDBM50561912(CHEMBL4798823)
Affinity DataIC50: 8.30E+4nMAssay Description:Inhibition of human SIRT2 defatty-acylation activity using peptide substrate in presence of NAD+ by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
LigandPNGBDBM50561912(CHEMBL4798823)
Affinity DataIC50: 8.30E+4nMAssay Description:Inhibition of human SIRT3 deacetylation activity using H3K9Ac as substrate preincubated for 15 mins in presence of NAD+ followed by substrate additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed