BDBM50563841 CHEMBL4786299

SMILES CC#C[C@H](CC(O)=O)c1ccc(OCc2ccc(CN3CCC4(CC3)C=Cc3ccccc43)cc2)cc1F

InChI Key InChIKey=NEGIWTYBODMDQN-UHFFFAOYSA-N

Data  1 KI  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50563841   

TargetFree fatty acid receptor 1(Mouse)
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50563841(CHEMBL4786299)
Affinity DataEC50:  120nMAssay Description:Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arresti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50563841(CHEMBL4786299)
Affinity DataEC50:  190nMAssay Description:Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50563841(CHEMBL4786299)
Affinity DataKi:  410nMAssay Description:Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Rat)
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50563841(CHEMBL4786299)
Affinity DataEC50:  420nMAssay Description:Agonist activity at Prolink-tagged rat GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arrestin ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50563841(CHEMBL4786299)
Affinity DataEC50:  440nMAssay Description:Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50563841(CHEMBL4786299)
Affinity DataEC50:  680nMAssay Description:Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed