BDBM50564263 CHEMBL4788954

SMILES COc1ccc(cc1)-c1ccc2c(NC(=O)CCCCCCC(=O)NO)n[nH]c2c1

InChI Key InChIKey=OQKZYTUPMGUCDP-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50564263   

TargetHistone deacetylase 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50564263(CHEMBL4788954)
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant HDAC1 using Ac-RHKK(Acetyl)-AMC peptide as fluorogenic substrate pre-incubated for 30 mins followed by substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50564263(CHEMBL4788954)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of recombinant human C-terminal His/FLAG-tagged HDAC1 (1 to end residues) expressed in sf9 insect cells using Boc-Lys(Ac)-AMC as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50564263(CHEMBL4788954)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of HDAC1 in human HeLa nuclear extract using Boc-Lys(Ac)-AMC as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Jiangsu Key Laboratory For Functional Substance of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50564263(CHEMBL4788954)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of recombinant human full length C-terminal His-tagged HDAC8 expressed in sf9 insect cells using Boc-Lys(TFA)-AM as substrate incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Jiangsu Key Laboratory For Functional Substance of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50564263(CHEMBL4788954)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of HDAC8 in human HeLa nuclear extract using Boc-Lys(Ac)-AMC as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50564263(CHEMBL4788954)
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant HDAC2 using Ac-RHKK(Acetyl)-AMC peptide as fluorogenic substrate pre-incubated for 30 mins followed by substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Jiangsu Key Laboratory For Functional Substance of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50564263(CHEMBL4788954)
Affinity DataIC50: 4nMAssay Description:Inhibition of HDAC8 (unknown origin) using Fluoro-Substrate Peptide as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50564263(CHEMBL4788954)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of HDAC2 in human HeLa nuclear extract using Boc-Lys(Ac)-AMC as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50564263(CHEMBL4788954)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of recombinant human C-terminal His-tagged HDAC2 (1 to end residues) expressed in sf9 insect cells using Boc-Lys(Ac)-AMC as substrate incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed